KMID : 0882420070720050511
|
|
Korean Journal of Medicine 2007 Volume.72 No. 5 p.511 ~ p.521
|
|
Association between apolipoprotein E genetic polymorphism and the development of microalbuminuria in type 2 diabetic patients
|
|
Kwon Mi-Kwang
Rhee Sang-Youl Chon Suk Oh Seung-Joon Woo Jeong-Taek Kim Sung-Woon Kim Jin-Woo Kim Young-Seol
|
|
Abstract
|
|
|
Background : Apo E genetic polymorphism has been proposed as the one of the risk factors for diabetic nephropathy. We studied the association between Apo E genetic polymorphism and the development of microalbuminuria, which is the early stage of diabetic nephropathy.
Methods : Fifty eight subjects with normoalbuminuria and Thirty six subjects with microalbuminuria were enrolled. They were all type 2 diabetic patients who had normal renal function and a history of diabetes longer than a 10 years duration. We examined the mean HbA1c, total cholesterol and triglyceride levels for 10 years, and we also examined
several clinical characteristics. We determined the Apo E genotype by performing real time PCR.
Results : In the microalbuminuria group, compared with the normoalbuminuria group, the HbA1c (7.6¡¾1.3% vs 7.0¡¾0.9%, respectively, p=0.012) and mean creatinine (1.2¡¾0.7 mg/dL vs 1.0¡¾0.2 mg/dL, respectively, p=0.004) levels were
significantly higher, and the frequencies of the e3/e4 genotype (5.6% vs 20.7%, respectively, p=0.045) and the E4 carriers
(5.9% vs 22.8%, respectively, p=0.035) were significantly lower. On logistic regression analysis, the crude odds ratio of
being an E2 carrier and being an E4 carrier were 0.833 (95% CI: 0.245-2.833) and 0.205 (95% CI: 0.043-0.986),
respectively. However, the odds ratio after adjusted by HbA1c, hypertension, total cholesterol and triglyceride were 0.664
(95% CI: 0.134-3.289) and 0.365 (95% CI: 0.061-2.187), respectively. There were no correlations between being an Apo
E carrier and the lipid levels in the healthy controls and diabetic patients.
Conclusions : Being an E4 carrier might play a role in protecting against the development of microalbuminuria in
type 2 diabetic patients and there was no correlation among the Apo E genetic polymorphisms and the lipid
levels.(Korean J Med 72:511-521, 2007)
|
|
KEYWORD
|
|
Diabetes mellitus, Type 2, Apo E genetic polymorphisms, Microalbuminuira
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|